Completion of the entire hepatitis C virus life cycle in genetically humanized mice

Marcus Dorner, Joshua A. Horwitz, Bridget M. Donovan, Rachael N. Labitt, William C. Budell, Tamar Friling, Alexander Vogt, Maria Teresa Catanese, Takashi Satoh, Taro Kawai, Shizuo Akira, Mansun Law, Charles M. Rice () and Alexander Ploss ()
Additional contact information
Marcus Dorner: Center for the Study of Hepatitis C, The Rockefeller University
Joshua A. Horwitz: Center for the Study of Hepatitis C, The Rockefeller University
Bridget M. Donovan: Center for the Study of Hepatitis C, The Rockefeller University
Rachael N. Labitt: Center for the Study of Hepatitis C, The Rockefeller University
William C. Budell: Center for the Study of Hepatitis C, The Rockefeller University
Tamar Friling: Center for the Study of Hepatitis C, The Rockefeller University
Alexander Vogt: Center for the Study of Hepatitis C, The Rockefeller University
Maria Teresa Catanese: Center for the Study of Hepatitis C, The Rockefeller University
Takashi Satoh: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
Taro Kawai: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
Shizuo Akira: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
Mansun Law: The Scripps Research Institute
Charles M. Rice: Center for the Study of Hepatitis C, The Rockefeller University
Alexander Ploss: Center for the Study of Hepatitis C, The Rockefeller University

Nature, 2013, vol. 501, issue 7466, 237-241

Abstract: The entire hepatitis C virus life cycle can be recapitulated in an inbred mouse model, allowing preclinical assessment of antiviral therapeutics and vaccines.

Date: 2013
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DOI: 10.1038/nature12427

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