Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

Greg M. Delgoffe, Seng-Ryong Woo, Meghan E. Turnis, David M. Gravano, Cliff Guy, Abigail E. Overacre, Matthew L. Bettini, Peter Vogel, David Finkelstein, Jody Bonnevier, Creg J. Workman and Dario A. A. Vignali ()
Additional contact information
Greg M. Delgoffe: St Jude Children's Research Hospital
Seng-Ryong Woo: St Jude Children's Research Hospital
Meghan E. Turnis: St Jude Children's Research Hospital
David M. Gravano: St Jude Children's Research Hospital
Cliff Guy: St Jude Children's Research Hospital
Abigail E. Overacre: St Jude Children's Research Hospital
Matthew L. Bettini: St Jude Children's Research Hospital
Peter Vogel: St Jude Children's Research Hospital
David Finkelstein: Computational Biology, St Jude Children's Research Hospital
Jody Bonnevier: R&D Systems Inc.
Creg J. Workman: St Jude Children's Research Hospital
Dario A. A. Vignali: St Jude Children's Research Hospital

Nature, 2013, vol. 501, issue 7466, 252-256

Abstract: Neuropilin-1 (Nrp1) on regulatory T (Treg) cells is shown to interact with semaphorin-4a (Sema4a) to promote a program of Treg-cell stability and survival, in part through PTEN-mediated modulation of Akt signalling; Nrp1-deficient Treg cells can maintain immune homeostasis but fail to suppress in inflammatory sites, such as tumours, providing an attractive immunotherapeutic target for the treatment of cancers.

Date: 2013
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DOI: 10.1038/nature12428

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