Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou (), Jacob R. Haling, Huifen Chen, Kyung Song, Steve Price, Robert Heald, Joanne F. M. Hewitt, Mark Zak, Ariana Peck, Christine Orr, Mark Merchant, Klaus P. Hoeflich, Jocelyn Chan, Shiuh-Ming Luoh, Daniel J. Anderson, Mary J. C. Ludlam, Christian Wiesmann, Mark Ultsch, Lori S. Friedman, Shiva Malek and Marcia Belvin ()
Additional contact information
Georgia Hatzivassiliou: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jacob R. Haling: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Huifen Chen: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kyung Song: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Steve Price: Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK
Robert Heald: Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK
Joanne F. M. Hewitt: Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK
Mark Zak: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ariana Peck: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Christine Orr: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Mark Merchant: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Klaus P. Hoeflich: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jocelyn Chan: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Shiuh-Ming Luoh: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Daniel J. Anderson: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Mary J. C. Ludlam: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Christian Wiesmann: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Mark Ultsch: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Lori S. Friedman: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Shiva Malek: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Marcia Belvin: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2013, vol. 501, issue 7466, 232-236

Abstract: The mechanism of action of three different allosteric MEK inhibitors that target the MAP kinase pathway is investigated, and their efficacy is shown to be explained by the distinct mechanisms regulating MEK activation in KRAS- versus BRAF-driven tumours; this work provides a rationale for designing more effective cancer therapies for these common genetic subtypes of cancer.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature12441 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:501:y:2013:i:7466:d:10.1038_nature12441

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12441

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().