A type III effector antagonizes death receptor signalling during bacterial gut infection

Jaclyn S. Pearson, Cristina Giogha, Sze Ying Ong, Catherine L. Kennedy, Michelle Kelly, Keith S. Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare V. L. Oates, Ali Zaid, Sabrina Mühlen, Valerie F. Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A. Williamson, Lorraine A. O’Reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, Andrew I. Webb, John Silke, Andreas Strasser, Gad Frankel and Elizabeth L. Hartland ()
Additional contact information
Jaclyn S. Pearson: University of Melbourne, Victoria 3010, Australia
Cristina Giogha: University of Melbourne, Victoria 3010, Australia
Sze Ying Ong: University of Melbourne, Victoria 3010, Australia
Catherine L. Kennedy: University of Melbourne, Victoria 3010, Australia
Michelle Kelly: University of Melbourne, Victoria 3010, Australia
Keith S. Robinson: MRC Centre for Molecular Bacteriology and Infection, Imperial College, London SW7 2AZ, UK
Tania Wong Fok Lung: University of Melbourne, Victoria 3010, Australia
Ashley Mansell: Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Victoria 3010, Australia
Patrice Riedmaier: University of Melbourne, Victoria 3010, Australia
Clare V. L. Oates: University of Melbourne, Victoria 3010, Australia
Ali Zaid: University of Melbourne, Victoria 3010, Australia
Sabrina Mühlen: University of Melbourne, Victoria 3010, Australia
Valerie F. Crepin: MRC Centre for Molecular Bacteriology and Infection, Imperial College, London SW7 2AZ, UK
Olivier Marches: Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
Ching-Seng Ang: Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia
Nicholas A. Williamson: Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia
Lorraine A. O’Reilly: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Aleksandra Bankovacki: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Ueli Nachbur: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Giuseppe Infusini: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Andrew I. Webb: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
John Silke: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Andreas Strasser: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Gad Frankel: MRC Centre for Molecular Bacteriology and Infection, Imperial College, London SW7 2AZ, UK
Elizabeth L. Hartland: University of Melbourne, Victoria 3010, Australia

Nature, 2013, vol. 501, issue 7466, 247-251

Abstract: Colonizing enteric bacteria are shown to inhibit the antimicrobial process of host cell apoptosis through the action of NleB1, a type III secretion system effector with N-acetylglucosamine transferase activity, which can bind and modify eukaryotic death-domain-containing proteins.

Date: 2013
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DOI: 10.1038/nature12524

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