Bacterial colonization factors control specificity and stability of the gut microbiota

S. Melanie Lee, Gregory P. Donaldson, Zbigniew Mikulski, Silva Boyajian, Klaus Ley and Sarkis K. Mazmanian ()
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S. Melanie Lee: California Institute of Technology
Gregory P. Donaldson: California Institute of Technology
Zbigniew Mikulski: La Jolla Institute for Allergy and Immunology
Silva Boyajian: California Institute of Technology
Klaus Ley: La Jolla Institute for Allergy and Immunology
Sarkis K. Mazmanian: California Institute of Technology

Nature, 2013, vol. 501, issue 7467, 426-429

Abstract: Germ-free mice mono-associated with a single species of Bacteroides are found to be resistant to further colonization by the same, but not different, species; a unique class of polysaccharide utilization loci that is required for the penetration of the colonic mucus and colonization of the crypt channel niche is discovered that explains this observed species-specific saturable colonization.

Date: 2013
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DOI: 10.1038/nature12447

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