DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

Maria A. Ermolaeva, Alexandra Segref, Alexander Dakhovnik, Hui-Ling Ou, Jennifer I. Schneider, Olaf Utermöhlen, Thorsten Hoppe and Björn Schumacher ()
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Maria A. Ermolaeva: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Alexandra Segref: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Alexander Dakhovnik: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Hui-Ling Ou: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Jennifer I. Schneider: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Olaf Utermöhlen: Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany
Thorsten Hoppe: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Björn Schumacher: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany

Nature, 2013, vol. 501, issue 7467, 416-420

Abstract: In Caenorhabditis elegans, genome instability in the form of exogenous and endogenous DNA damage in germ cells evokes elevated heat- and oxidative-stress resistance in somatic tissues; this is mediated by MPK-1, which triggers the induction of putative secreted peptides associated with innate immunity, leading to activation of the ubiquitin–proteasome system.

Date: 2013
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DOI: 10.1038/nature12452

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