The structural mechanism of KCNH-channel regulation by the eag domain

Yoni Haitin, Anne E. Carlson and William N. Zagotta ()
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Yoni Haitin: University of Washington School of Medicine
Anne E. Carlson: University of Washington School of Medicine
William N. Zagotta: University of Washington School of Medicine

Nature, 2013, vol. 501, issue 7467, 444-448

Abstract: An X-ray crystal structure of two intracellular domains of a mouse KCNH voltage-dependent potassium channel, EAG1, is presented: the structure reveals that the eag domain interacts directly with the cyclic nucleotide-binding homology domain (CNBHD), and that many KCNH-associated disease mutations are localized to the eag domain–CNBHD interface.

Date: 2013
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DOI: 10.1038/nature12487

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