Tumour heterogeneity and cancer cell plasticity

Corbin E. Meacham and Sean J. Morrison ()
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Corbin E. Meacham: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
Sean J. Morrison: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center

Nature, 2013, vol. 501, issue 7467, 328-337

Abstract: Abstract Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny. However, it remains unclear what fraction of cancers follow the stem-cell model and what clinical behaviours the model explains. Studies using lineage tracing and deep sequencing could have implications for the cancer stem-cell model and may help to determine the extent to which it accounts for therapy resistance and disease progression.

Date: 2013
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DOI: 10.1038/nature12624

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