The causes and consequences of genetic heterogeneity in cancer evolution

Rebecca A. Burrell, Nicholas McGranahan, Jiri Bartek and Charles Swanton ()
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Rebecca A. Burrell: Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute
Nicholas McGranahan: Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute
Jiri Bartek: Danish Cancer Society Research Center
Charles Swanton: Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute

Nature, 2013, vol. 501, issue 7467, 338-345

Abstract: Abstract Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies.

Date: 2013
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DOI: 10.1038/nature12625

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