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Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice

Jessica A. Belser, Kortney M. Gustin, Melissa B. Pearce, Taronna R. Maines, Hui Zeng, Claudia Pappas, Xiangjie Sun, Paul J. Carney, Julie M. Villanueva, James Stevens, Jacqueline M. Katz and Terrence M. Tumpey ()
Additional contact information
Jessica A. Belser: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Kortney M. Gustin: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Melissa B. Pearce: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Taronna R. Maines: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Hui Zeng: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Claudia Pappas: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Xiangjie Sun: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Paul J. Carney: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Julie M. Villanueva: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
James Stevens: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Jacqueline M. Katz: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention
Terrence M. Tumpey: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention

Nature, 2013, vol. 501, issue 7468, 556-559

Abstract: The new H7N9 influenza virus, recently emerged in China, can replicate in human airway cells and in the respiratory tract of ferrets to a higher level than can seasonal H3N2 virus and shows higher lethality in mice than genetically related H7N9 and H9N2 viruses, but shows limited transmission in ferrets by respiratory droplets.

Date: 2013
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DOI: 10.1038/nature12391

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