Wapl is an essential regulator of chromatin structure and chromosome segregation

Antonio Tedeschi, Gordana Wutz, Sébastien Huet, Markus Jaritz, Annelie Wuensche, Erika Schirghuber, Iain Finley Davidson, Wen Tang, David A. Cisneros, Venugopal Bhaskara, Tomoko Nishiyama, Alipasha Vaziri, Anton Wutz, Jan Ellenberg and Jan-Michael Peters ()
Additional contact information
Antonio Tedeschi: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Gordana Wutz: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Sébastien Huet: Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany
Markus Jaritz: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Annelie Wuensche: Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany
Erika Schirghuber: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Iain Finley Davidson: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Wen Tang: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
David A. Cisneros: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Venugopal Bhaskara: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Tomoko Nishiyama: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Alipasha Vaziri: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Anton Wutz: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Jan Ellenberg: Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany
Jan-Michael Peters: Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria

Nature, 2013, vol. 501, issue 7468, 564-568

Abstract: Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural role in interphase chromosome organization.

Date: 2013
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DOI: 10.1038/nature12471

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