A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex

Sandra J. Kuhlman, Nicholas D. Olivas, Elaine Tring, Taruna Ikrar, Xiangmin Xu () and Joshua T. Trachtenberg ()
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Sandra J. Kuhlman: David Geffen School of Medicine, University of California
Nicholas D. Olivas: University of California
Elaine Tring: David Geffen School of Medicine, University of California
Taruna Ikrar: University of California
Xiangmin Xu: University of California
Joshua T. Trachtenberg: David Geffen School of Medicine, University of California

Nature, 2013, vol. 501, issue 7468, 543-546

Abstract: The role of parvalbumin (PV)-positive interneurons in ocular dominance plasticity (ODP) has been a point of contention; here PV-positive cells are shown to initiate competitive periods of plasticity during the critical periods of eye development when ODP occurs, and transient reductions in inhibitory firing from PV-positive cells provides a return to normal firing rates in excitatory neurons, a key step in ODP progression.

Date: 2013
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DOI: 10.1038/nature12485

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