Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

Brett H. Herzog, Jianxin Fu, Stephen J. Wilson, Paul R. Hess, Aslihan Sen, J. Michael McDaniel, Yanfang Pan, Minjia Sheng, Tadayuki Yago, Robert Silasi-Mansat, Samuel McGee, Frauke May, Bernhard Nieswandt, Andrew J. Morris, Florea Lupu, Shaun R. Coughlin, Rodger P. McEver, Hong Chen, Mark L. Kahn and Lijun Xia ()
Additional contact information
Brett H. Herzog: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Jianxin Fu: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Stephen J. Wilson: Cardiovascular Research Institute, University of California
Paul R. Hess: University of Pennsylvania
Aslihan Sen: University of Pennsylvania
J. Michael McDaniel: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Yanfang Pan: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Minjia Sheng: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Tadayuki Yago: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Robert Silasi-Mansat: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Samuel McGee: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Frauke May: University Hospital Wurzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, 97080 Wurzburg, Germany
Bernhard Nieswandt: University Hospital Wurzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, 97080 Wurzburg, Germany
Andrew J. Morris: University of Kentucky and Lexington Veterans Affairs Medical Center
Florea Lupu: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Shaun R. Coughlin: Cardiovascular Research Institute, University of California
Rodger P. McEver: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Hong Chen: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
Mark L. Kahn: University of Pennsylvania
Lijun Xia: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation

Nature, 2013, vol. 502, issue 7469, 105-109

Abstract: A transmembrane O-glycoprotein podoplanin (PDPN) expressed on fibroblastic reticular cells is the activating ligand for platelet receptor CLEC-2; this interaction leads to perivenular release of sphingosine-1-phosphate and expression of VE-cadherin on high endothelial venules, a key process for the maintenance of vascular integrity in lymph nodes.

Date: 2013
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DOI: 10.1038/nature12501

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