Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

Lilian Kabeche and Duane A. Compton ()
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Lilian Kabeche: Geisel School of Medicine at Dartmouth
Duane A. Compton: Geisel School of Medicine at Dartmouth

Nature, 2013, vol. 502, issue 7469, 110-113

Abstract: Cyclin A is shown to maintain unstable kinetochore–microtubule (k–MT) attachments in prometaphase in order to allow for error correction; at the prometaphase–metaphase switch, k-MT attachments are stabilized when cyclin A drops below threshold levels.

Date: 2013
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DOI: 10.1038/nature12507

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