Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters

Guus B. Erkens, Inga Hänelt, Joris M. H. Goudsmits, Dirk Jan Slotboom () and Antoine M. van Oijen ()
Additional contact information
Guus B. Erkens: University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Inga Hänelt: University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Joris M. H. Goudsmits: University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Dirk Jan Slotboom: University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Antoine M. van Oijen: University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands

Nature, 2013, vol. 502, issue 7469, 119-123

Abstract: Glutamate transporters are integral membrane proteins that facilitate neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons, the mechanism of transport involves transitions between extracellular- and intracellular-facing conformations; here the authors used single-molecule fluorescence resonance energy transfer imaging to directly observe conformational dynamics in trimers of a bacterial homologue of glutamate transporters that was embedded in the membrane.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature12538 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12538

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12538

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().