Vinylogous chain branching catalysed by a dedicated polyketide synthase module

Tom Bretschneider, Joel B. Heim, Daniel Heine, Robert Winkler, Benjamin Busch, Björn Kusebauch, Thilo Stehle, Georg Zocher () and Christian Hertweck ()
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Tom Bretschneider: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany
Joel B. Heim: Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany
Daniel Heine: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany
Robert Winkler: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany
Benjamin Busch: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany
Björn Kusebauch: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany
Thilo Stehle: Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany
Georg Zocher: Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany
Christian Hertweck: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany

Nature, 2013, vol. 502, issue 7469, 124-128

Abstract: This study shows the structural and biochemical characterization of a new type of polyketide synthase module that catalyses the vinylogous addition of a malonyl unit to an unsaturated thioester, generating a branch in the growing polyketide chain; this characterization provides a mechanism by which the structural diversity of polyketide natural products can be increased.

Date: 2013
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DOI: 10.1038/nature12588

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