Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

Atsuya Nishiyama (), Luna Yamaguchi, Jafar Sharif, Yoshikazu Johmura, Takeshi Kawamura, Keiko Nakanishi, Shintaro Shimamura, Kyohei Arita, Tatsuhiko Kodama, Fuyuki Ishikawa, Haruhiko Koseki and Makoto Nakanishi ()
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Atsuya Nishiyama: Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Luna Yamaguchi: Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Jafar Sharif: RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan
Yoshikazu Johmura: Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Takeshi Kawamura: Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan
Keiko Nakanishi: Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan
Shintaro Shimamura: Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan
Kyohei Arita: Graduate School of Medical Life Sciences, Yokohama City University, 1-7-29, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan
Tatsuhiko Kodama: Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan
Fuyuki Ishikawa: Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Haruhiko Koseki: RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan
Makoto Nakanishi: Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan

Nature, 2013, vol. 502, issue 7470, 249-253

Abstract: The RING finger domain protein Uhrf1 is known to have an important role in DNA methylation pattern maintenance through the recruitment of the methyltransferase Dnmt1 to hemimethylated DNA sites: here, Uhrf1 is shown to act as a ubiquitin ligase for H3, an essential step in Dnmt1 recruitment.

Date: 2013
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DOI: 10.1038/nature12488

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