Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

Zaiming Tang, Mary Grace Lin, Timothy Richard Stowe, She Chen, Muyuan Zhu, Tim Stearns, Brunella Franco and Qing Zhong ()
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Zaiming Tang: Center for Autophagy Research, University of Texas Southwestern Medical Center
Mary Grace Lin: Biophysics and Structural Biology, University of California
Timothy Richard Stowe: Stanford University
She Chen: National Institute of Biological Sciences
Muyuan Zhu: State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University
Tim Stearns: Stanford University
Brunella Franco: Medical Genetics Services, Federico II University, Via Pietro Castellino 111, Naples, Italy
Qing Zhong: Center for Autophagy Research, University of Texas Southwestern Medical Center

Nature, 2013, vol. 502, issue 7470, 254-257

Abstract: The primary cilium is a microtubule-based organelle that functions in sensory and signal transduction; the authors demonstrate here that autophagic degradation of the oral-facial-digital syndrome 1 (OFD1) protein at centriolar satellites promotes primary cilium biogenesis, and that autophagy modulation might provide a novel means of ciliopathy treatment.

Date: 2013
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DOI: 10.1038/nature12606

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