Temperature triggers immune evasion by Neisseria meningitidis

Edmund Loh, Elisabeth Kugelberg, Alexander Tracy, Qian Zhang, Bridget Gollan, Helen Ewles, Ronald Chalmers, Vladimir Pelicic and Christoph M. Tang ()
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Edmund Loh: Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK
Elisabeth Kugelberg: Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
Alexander Tracy: Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK
Qian Zhang: Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
Bridget Gollan: Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
Helen Ewles: Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
Ronald Chalmers: School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2NR, UK
Vladimir Pelicic: Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK
Christoph M. Tang: Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK

Nature, 2013, vol. 502, issue 7470, 237-240

Abstract: Three Neisseria meningitidis RNA thermosensors important for resistance against complement-mediated immune killing are identified, located in the 5′ untranslated regions of genes necessary for capsule biosynthesis, expression of factor H binding protein and sialyation of lipolysaccharide; increased temperature may act as a warning signal for the bacterium, prompting it to enhance mechanisms of immune evasion.

Date: 2013
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DOI: 10.1038/nature12616

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