Functional interaction between autophagy and ciliogenesis

Olatz Pampliega, Idil Orhon, Bindi Patel, Sunandini Sridhar, Antonio Díaz-Carretero, Isabelle Beau, Patrice Codogno, Birgit H. Satir, Peter Satir () and Ana Maria Cuervo ()
Additional contact information
Olatz Pampliega: Albert Einstein College of Medicine
Idil Orhon: INSERM U845
Bindi Patel: Albert Einstein College of Medicine
Sunandini Sridhar: Albert Einstein College of Medicine
Antonio Díaz-Carretero: Albert Einstein College of Medicine
Isabelle Beau: INSERM U984; 92296 Châtenay-Malabry, France
Patrice Codogno: INSERM U845
Birgit H. Satir: Albert Einstein College of Medicine
Peter Satir: Albert Einstein College of Medicine
Ana Maria Cuervo: Albert Einstein College of Medicine

Nature, 2013, vol. 502, issue 7470, 194-200

Abstract: Abstract Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature12639 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12639

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12639

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().