HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Carrie A. Adelman, Rafal L. Lolo, Nicolai J. Birkbak, Olga Murina, Kenichiro Matsuzaki, Zuzana Horejsi, Kalindi Parmar, Valérie Borel, J. Mark Skehel, Gordon Stamp, Alan D’Andrea, Alessandro A. Sartori, Charles Swanton and Simon J. Boulton ()
Additional contact information
Carrie A. Adelman: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Rafal L. Lolo: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Nicolai J. Birkbak: Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark
Olga Murina: Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Kenichiro Matsuzaki: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Zuzana Horejsi: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Kalindi Parmar: Dana Farber Cancer Institute
Valérie Borel: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
J. Mark Skehel: Protein Analysis and Proteomics Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Gordon Stamp: Experimental Histopathology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Alan D’Andrea: Dana Farber Cancer Institute
Alessandro A. Sartori: Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Charles Swanton: Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Simon J. Boulton: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK

Nature, 2013, vol. 502, issue 7471, 381-384

Abstract: Interstrand crosslink (ICL) repair involves proteins whose mutation results in the disorder Fanconi anaemia: here gene knockdown studies in mice show that the absence of HELQ, a protein previously implicated in ICL repair, compromises germ cell development and results in tumour predisposition due to defective recombination at damaged replication forks.

Date: 2013
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DOI: 10.1038/nature12565

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