Migrating bubble during break-induced replication drives conservative DNA synthesis

Natalie Saini, Sreejith Ramakrishnan, Rajula Elango, Sandeep Ayyar, Yu Zhang, Angela Deem, Grzegorz Ira, James E. Haber, Kirill S. Lobachev () and Anna Malkova ()
Additional contact information
Natalie Saini: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Sreejith Ramakrishnan: School of Science, IUPUI, Indianapolis, Indiana 46202-5132, USA
Rajula Elango: School of Science, IUPUI, Indianapolis, Indiana 46202-5132, USA
Sandeep Ayyar: School of Science, IUPUI, Indianapolis, Indiana 46202-5132, USA
Yu Zhang: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Angela Deem: School of Science, IUPUI, Indianapolis, Indiana 46202-5132, USA
Grzegorz Ira: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
James E. Haber: Department of Biology and Rosenstiel Basic Medical Sciences Research Center
Kirill S. Lobachev: School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Anna Malkova: School of Science, IUPUI, Indianapolis, Indiana 46202-5132, USA

Nature, 2013, vol. 502, issue 7471, 389-392

Abstract: This paper demonstrates that the mechanism of break-induced replication (BIR) is significantly different from S-phase replication, as it proceeds via a migrating bubble driven by Pif1 helicase, results in conservative inheritance of newly synthesized DNA, and is inherently mutagenic.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature12584 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:502:y:2013:i:7471:d:10.1038_nature12584

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12584

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().