Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

Marenda A. Wilson, YoungHo Kwon, Yuanyuan Xu, Woo-Hyun Chung, Peter Chi, Hengyao Niu, Ryan Mayle, Xuefeng Chen, Anna Malkova, Patrick Sung () and Grzegorz Ira ()
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Marenda A. Wilson: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
YoungHo Kwon: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Yuanyuan Xu: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Woo-Hyun Chung: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Peter Chi: Institute of Biochemical Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan
Hengyao Niu: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Ryan Mayle: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Xuefeng Chen: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Anna Malkova: School of Science, IUPUI, Indianapolis, Indiana 46202, USA
Patrick Sung: Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Grzegorz Ira: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA

Nature, 2013, vol. 502, issue 7471, 393-396

Abstract: This paper demonstrates that Pif1 helicase works with polymerase d to promote DNA synthesis through a migrating D-loop, a mechanism used to copy tens of kilobases during repair of chromosome breaks by break-induced replication (BIR).

Date: 2013
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DOI: 10.1038/nature12585

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