Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

Caroline Goujon, Olivier Moncorgé, Hélène Bauby, Tomas Doyle, Christopher C. Ward, Torsten Schaller, Stéphane Hué, Wendy S. Barclay, Reiner Schulz and Michael H. Malim ()
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Caroline Goujon: King’s College London, London SE1 9RT, UK
Olivier Moncorgé: Section of Virology, Imperial College London, London W2 1PG, UK
Hélène Bauby: King’s College London, London SE1 9RT, UK
Tomas Doyle: King’s College London, London SE1 9RT, UK
Christopher C. Ward: King’s College London, London SE1 9RT, UK
Torsten Schaller: King’s College London, London SE1 9RT, UK
Stéphane Hué: Centre for Medical Molecular Virology, University College London, London WC1 6RT, UK
Wendy S. Barclay: Section of Virology, Imperial College London, London W2 1PG, UK
Reiner Schulz: King’s College London, London SE1 9RT, UK
Michael H. Malim: King’s College London, London SE1 9RT, UK

Nature, 2013, vol. 502, issue 7472, 559-562

Abstract: Here, a protein known as MX2 is shown to be a major effector of interferon-α-mediated resistance to HIV-1 infection: susceptibility of the HIV-1 virus to inhibition by MX2 is dictated by the Capsid region of the viral Gag protein, and inhibition occurs at a late post-entry step of infection.

Date: 2013
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DOI: 10.1038/nature12542

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