Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

Aaron M. Ring, Aashish Manglik, Andrew C. Kruse, Michael D. Enos, William I. Weis, K. Christopher Garcia () and Brian K. Kobilka ()
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Aaron M. Ring: Stanford University
Aashish Manglik: Stanford University
Andrew C. Kruse: Stanford University
Michael D. Enos: Stanford University
William I. Weis: Stanford University
K. Christopher Garcia: Stanford University
Brian K. Kobilka: Stanford University

Nature, 2013, vol. 502, issue 7472, 575-579

Abstract: Here, by developing a high-affinity camelid antibody fragment that stabilizes the active state of the β2-adrenoceptor, the X-ray crystal structures of the receptor in complex with three agonists, including adrenaline, were determined.

Date: 2013
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DOI: 10.1038/nature12572

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