Spatial organization within a niche as a determinant of stem-cell fate

Panteleimon Rompolas, Kailin R. Mesa and Valentina Greco ()
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Panteleimon Rompolas: Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine
Kailin R. Mesa: Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine
Valentina Greco: Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine

Nature, 2013, vol. 502, issue 7472, 513-518

Abstract: Abstract Stem-cell niches in mammalian tissues are often heterogeneous and compartmentalized; however, whether distinct niche locations determine different stem-cell fates remains unclear. To test this hypothesis, here we use the mouse hair follicle niche and combine intravital microscopy with genetic lineage tracing to re-visit the same stem-cell lineages, from their exact place of origin, throughout regeneration in live mice. Using this method, we show directly that the position of a stem cell within the hair follicle niche can predict whether it is likely to remain uncommitted, generate precursors or commit to a differentiated fate. Furthermore, using laser ablation we demonstrate that hair follicle stem cells are dispensable for regeneration, and that epithelial cells, which do not normally participate in hair growth, re-populate the lost stem-cell compartment and sustain hair regeneration. This study provides a general model for niche-induced fate determination in adult tissues.

Date: 2013
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DOI: 10.1038/nature12602

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