A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use

Sihao Liu, Jonathan D. Brown, Kristopher J. Stanya, Edwin Homan, Mathias Leidl, Karen Inouye, Prerna Bhargava, Matthew R. Gangl, Lingling Dai, Ben Hatano, Gökhan S. Hotamisligil, Alan Saghatelian, Jorge Plutzky and Chih-Hao Lee ()
Additional contact information
Sihao Liu: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Jonathan D. Brown: Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Kristopher J. Stanya: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Edwin Homan: Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Mathias Leidl: Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Karen Inouye: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Prerna Bhargava: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Matthew R. Gangl: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Lingling Dai: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Ben Hatano: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Gökhan S. Hotamisligil: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Alan Saghatelian: Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Jorge Plutzky: Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Chih-Hao Lee: Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA

Nature, 2013, vol. 502, issue 7472, 550-554

Abstract: How the liver communicates with peripheral tissues to achieve metabolic homeostasis is poorly defined; here the authors show that the nuclear hormone receptor PPARδ regulates de novo lipogenesis in the liver and orchestrates fat use by muscle via a circulating lipid.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature12710 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12710

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12710

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().