Chromatin dynamics during cellular reprogramming

Effie Apostolou and Konrad Hochedlinger ()
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Effie Apostolou: Massachusetts General Hospital Center for Regenerative Medicine
Konrad Hochedlinger: Massachusetts General Hospital Center for Regenerative Medicine

Nature, 2013, vol. 502, issue 7472, 462-471

Abstract: Abstract Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.

Date: 2013
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DOI: 10.1038/nature12749

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