Discovery of new enzymes and metabolic pathways by using structure and genome context

Suwen Zhao, Ritesh Kumar, Ayano Sakai, Matthew W. Vetting, B. McKay Wood, Shoshana Brown, Jeffery B. Bonanno, Brandan S. Hillerich, Ronald D. Seidel, Patricia C. Babbitt (), Steven C. Almo (), Jonathan V. Sweedler (), John A. Gerlt (), John E. Cronan () and Matthew P. Jacobson ()
Additional contact information
Suwen Zhao: University of California
Ritesh Kumar: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Ayano Sakai: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Matthew W. Vetting: Albert Einstein College of Medicine
B. McKay Wood: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Shoshana Brown: University of California
Jeffery B. Bonanno: Albert Einstein College of Medicine
Brandan S. Hillerich: Albert Einstein College of Medicine
Ronald D. Seidel: Albert Einstein College of Medicine
Patricia C. Babbitt: University of California
Steven C. Almo: Albert Einstein College of Medicine
Jonathan V. Sweedler: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
John A. Gerlt: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
John E. Cronan: Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Matthew P. Jacobson: University of California

Nature, 2013, vol. 502, issue 7473, 698-702

Abstract: Pathway docking (in silico docking of metabolites to several enzymes and binding proteins in a metabolic pathway) enables the discovery of a catabolic pathway for the osmolyte trans-4-hydroxy-l-proline betaine.

Date: 2013
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DOI: 10.1038/nature12576

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