Visualizing virus assembly intermediates inside marine cyanobacteria

Wei Dai, Caroline Fu, Desislava Raytcheva, John Flanagan, Htet A. Khant, Xiangan Liu, Ryan H. Rochat, Cameron Haase-Pettingell, Jacqueline Piret, Steve J. Ludtke, Kuniaki Nagayama, Michael F. Schmid, Jonathan A. King and Wah Chiu ()
Additional contact information
Wei Dai: National Center for Macromolecular Imaging, Baylor College of Medicine
Caroline Fu: National Center for Macromolecular Imaging, Baylor College of Medicine
Desislava Raytcheva: Massachusetts Institute of Technology
John Flanagan: National Center for Macromolecular Imaging, Baylor College of Medicine
Htet A. Khant: National Center for Macromolecular Imaging, Baylor College of Medicine
Xiangan Liu: National Center for Macromolecular Imaging, Baylor College of Medicine
Ryan H. Rochat: National Center for Macromolecular Imaging, Baylor College of Medicine
Cameron Haase-Pettingell: Massachusetts Institute of Technology
Jacqueline Piret: Northeastern University
Steve J. Ludtke: National Center for Macromolecular Imaging, Baylor College of Medicine
Kuniaki Nagayama: National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan
Michael F. Schmid: National Center for Macromolecular Imaging, Baylor College of Medicine
Jonathan A. King: Massachusetts Institute of Technology
Wah Chiu: National Center for Macromolecular Imaging, Baylor College of Medicine

Nature, 2013, vol. 502, issue 7473, 707-710

Abstract: This study reports the first application of Zernike phase contrast (ZPC) electron cryo-tomography to examine cellular processes without the need for labelling or sectioning; the technique is used to visualize the maturation of the cyanophage Syn5 inside its host cell, identifying subcellular compartments and five distinct Syn5 assembly intermediates.

Date: 2013
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DOI: 10.1038/nature12604

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