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Single-molecule fluorescence probes dynamics of barrier crossing

Hoi Sung Chung () and William A. Eaton ()
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Hoi Sung Chung: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
William A. Eaton: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

Nature, 2013, vol. 502, issue 7473, 685-688

Abstract: Here the Kramers diffusion coefficient and free-energy barrier are characterized for the first time through single-molecule fluorescence measurements of the temperature- and viscosity-dependence of the transition path time for protein folding.

Date: 2013
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DOI: 10.1038/nature12649

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