Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo

Spencer L. Smith (), Ikuko T. Smith, Tiago Branco and Michael Häusser ()
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Spencer L. Smith: Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Ikuko T. Smith: Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Tiago Branco: Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Michael Häusser: Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK

Nature, 2013, vol. 503, issue 7474, 115-120

Abstract: Neuronal dendrites are not passive cables, but whether their excitability contributes to computation at the cell’s soma has been uncertain; by observing and interfering with dendritic ‘spikes’ during sensory stimulation, it is now shown that active dendritic processing enhances somatic orientation selectivity, a fundamental brain computation.

Date: 2013
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DOI: 10.1038/nature12600

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