A directional switch of integrin signalling and a new anti-thrombotic strategy

Bo Shen, Xiaojuan Zhao, Kelly A. O’Brien, Aleksandra Stojanovic-Terpo, M. Keegan Delaney, Kyungho Kim, Jaehyung Cho, Stephen C.-T. Lam and Xiaoping Du ()
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Bo Shen: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Xiaojuan Zhao: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Kelly A. O’Brien: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Aleksandra Stojanovic-Terpo: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
M. Keegan Delaney: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Kyungho Kim: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Jaehyung Cho: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Stephen C.-T. Lam: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
Xiaoping Du: University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA

Nature, 2013, vol. 503, issue 7474, 131-135

Abstract: The direction of integrin signalling is found to be determined by the coordinated and opposing binding waves of talin and Gα13 to the same region of the integrin β3 cytoplasmic domain at mutually exclusive but distinct sites, and a potent new anti-thrombotic drug that does not cause bleeding is designed on the basis of these findings.

Date: 2013
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DOI: 10.1038/nature12613

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