Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

Elizabeth E. Gerber, Elena M. Gallo, Stefani C. Fontana, Elaine C. Davis, Fredrick M. Wigley, David L. Huso and Harry C. Dietz ()
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Elizabeth E. Gerber: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Elena M. Gallo: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Stefani C. Fontana: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Elaine C. Davis: McGill University, Montreal, Quebec H3A 2K6, Canada
Fredrick M. Wigley: Johns Hopkins University School of Medicine
David L. Huso: Johns Hopkins University School of Medicine
Harry C. Dietz: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine

Nature, 2013, vol. 503, issue 7474, 126-130

Abstract: Failure of integrin-mediated cell-matrix attachment is sufficient to initiate dermal fibrosis and autoimmunity in mouse models of scleroderma; integrin-modulating therapies prevent the recruitment and activation of plasmacytoid dendritic cells that appear central to immunological dysregulation and maintenance of the pro-fibrotic synthetic programme.

Date: 2013
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DOI: 10.1038/nature12614

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