Cooperation between brain and islet in glucose homeostasis and diabetes

Michael W. Schwartz (), Randy J. Seeley, Matthias H. Tschöp, Stephen C. Woods, Gregory J. Morton, Martin G. Myers and David D’Alessio
Additional contact information
Michael W. Schwartz: Diabetes and Obesity Center of Excellence, University of Washington
Randy J. Seeley: University of Cincinnati
Matthias H. Tschöp: Institute of Diabetes and Obesity, Technische Universität München, Munich 85764, Germany
Stephen C. Woods: University of Cincinnati
Gregory J. Morton: Diabetes and Obesity Center of Excellence, University of Washington
Martin G. Myers: University of Michigan
David D’Alessio: University of Cincinnati

Nature, 2013, vol. 503, issue 7474, 59-66

Abstract: An alternative view of diabetes is presented in which blood glucose homeostasis is achieved via collective actions of two regulatory systems: a brain-centred glucoregulatory system (BCGS), which works together with the pancreatic islets; defects in both systems may be required for diabetes to occur, and interventions targeting both systems may have greater therapeutic potential.

Date: 2013
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DOI: 10.1038/nature12709

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