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The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

Brenda L. Bloodgood, Nikhil Sharma, Heidi Adlman Browne, Alissa Z. Trepman and Michael E. Greenberg ()
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Brenda L. Bloodgood: Harvard Medical School
Nikhil Sharma: Harvard Medical School
Heidi Adlman Browne: Harvard Medical School
Alissa Z. Trepman: Harvard Medical School
Michael E. Greenberg: Harvard Medical School

Nature, 2013, vol. 503, issue 7474, 121-125

Abstract: The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes inhibitory synapses on the soma and destabilizes inhibitory synapses on the dendrites.

Date: 2013
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DOI: 10.1038/nature12743

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