Inhibitory signalling to the Arp2/3 complex steers cell migration

Irene Dang, Roman Gorelik, Carla Sousa-Blin, Emmanuel Derivery, Christophe Guérin, Joern Linkner, Maria Nemethova, Julien G. Dumortier, Florence A. Giger, Tamara A. Chipysheva, Valeria D. Ermilova, Sophie Vacher, Valérie Campanacci, Isaline Herrada, Anne-Gaelle Planson, Susan Fetics, Véronique Henriot, Violaine David, Ksenia Oguievetskaia, Goran Lakisic, Fabienne Pierre, Anika Steffen, Adeline Boyreau, Nadine Peyriéras, Klemens Rottner, Sophie Zinn-Justin, Jacqueline Cherfils, Ivan Bièche, Antonina Y. Alexandrova, Nicolas B. David, J. Victor Small, Jan Faix, Laurent Blanchoin and Alexis Gautreau ()
Additional contact information
Irene Dang: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Roman Gorelik: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Carla Sousa-Blin: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Emmanuel Derivery: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Christophe Guérin: Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV), Laboratoire de Physiologie Cellulaire et Végétale, CNRS/CEA/INRA/UJF, Grenoble 38054, France
Joern Linkner: Institute for Biophysical Chemistry, Hannover Medical School, Hannover 30625, Germany
Maria Nemethova: Institute of Molecular Biotechnology, Vienna 1030, Austria
Julien G. Dumortier: INSERM U1024, CNRS UMR8197, ENS, Institut de Biologie de l‘ENS, Paris 75005, France
Florence A. Giger: INSERM U1024, CNRS UMR8197, ENS, Institut de Biologie de l‘ENS, Paris 75005, France
Tamara A. Chipysheva: Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Russia
Valeria D. Ermilova: Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Russia
Sophie Vacher: Oncogenetic Laboratory, Institut Curie, Hôpital René Huguenin, Saint-Cloud 92210, France
Valérie Campanacci: Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Isaline Herrada: Laboratoire de Biologie Structurale et Radiobiologie (iBiTec-S), CNRS URA2096, CEA Saclay, Gif-sur-Yvette 91190, France
Anne-Gaelle Planson: Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Susan Fetics: Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Véronique Henriot: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Violaine David: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Ksenia Oguievetskaia: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Goran Lakisic: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Fabienne Pierre: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Anika Steffen: Institute of Genetics, University of Bonn, Bonn 53115, Germany
Adeline Boyreau: Institut des Systèmes Complexes & NeD, Institut de Neurobiologie Alfred Fessard, CNRS UPR3294, Gif-sur-Yvette 91190, France
Nadine Peyriéras: Institut des Systèmes Complexes & NeD, Institut de Neurobiologie Alfred Fessard, CNRS UPR3294, Gif-sur-Yvette 91190, France
Klemens Rottner: Institute of Genetics, University of Bonn, Bonn 53115, Germany
Sophie Zinn-Justin: Laboratoire de Biologie Structurale et Radiobiologie (iBiTec-S), CNRS URA2096, CEA Saclay, Gif-sur-Yvette 91190, France
Jacqueline Cherfils: Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France
Ivan Bièche: Oncogenetic Laboratory, Institut Curie, Hôpital René Huguenin, Saint-Cloud 92210, France
Antonina Y. Alexandrova: Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Russia
Nicolas B. David: INSERM U1024, CNRS UMR8197, ENS, Institut de Biologie de l‘ENS, Paris 75005, France
J. Victor Small: Institute of Molecular Biotechnology, Vienna 1030, Austria
Jan Faix: Institute for Biophysical Chemistry, Hannover Medical School, Hannover 30625, Germany
Laurent Blanchoin: Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV), Laboratoire de Physiologie Cellulaire et Végétale, CNRS/CEA/INRA/UJF, Grenoble 38054, France
Alexis Gautreau: Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France

Nature, 2013, vol. 503, issue 7475, 281-284

Abstract: A new protein, Arpin, is identified that inhibits the Arp2/3 complex and controls cell migration by decreasing cell speed and the directional persistence of migration; this inhibitory circuit is under the control of the small GTPase Rac1, and Arpin depletion causes faster lamellipodia protrusion and increased cell migration.

Date: 2013
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DOI: 10.1038/nature12611

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