Directional tissue migration through a self-generated chemokine gradient

Erika Donà, Joseph D. Barry, Guillaume Valentin, Charlotte Quirin, Anton Khmelinskii, Andreas Kunze, Sevi Durdu, Lionel R. Newton, Ana Fernandez-Minan, Wolfgang Huber, Michael Knop and Darren Gilmour ()
Additional contact information
Erika Donà: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Joseph D. Barry: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Guillaume Valentin: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Charlotte Quirin: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Anton Khmelinskii: Zentrum für Molekulare Biologie der Universität Heidelberg, Deutsches Krebsforschungszentrum, DKFZ–ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Andreas Kunze: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Sevi Durdu: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Lionel R. Newton: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Ana Fernandez-Minan: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Wolfgang Huber: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Michael Knop: Zentrum für Molekulare Biologie der Universität Heidelberg, Deutsches Krebsforschungszentrum, DKFZ–ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Darren Gilmour: EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Nature, 2013, vol. 503, issue 7475, 285-289

Abstract: It is widely accepted that migrating cells and tissues navigate along pre-patterned chemoattractant gradients; here it is shown that migrating tissues can also determine their own direction by generating local gradients of chemokine activity, via polarized receptor-mediated internalization, that are sufficient to ensure robust collective migration.

Date: 2013
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DOI: 10.1038/nature12635

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