A high-resolution map of the three-dimensional chromatin interactome in human cells

Fulai Jin, Yan Li, Jesse R. Dixon, Siddarth Selvaraj, Zhen Ye, Ah Young Lee, Chia-An Yen, Anthony D. Schmitt, Celso A. Espinoza and Bing Ren ()
Additional contact information
Fulai Jin: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Yan Li: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Jesse R. Dixon: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Siddarth Selvaraj: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Zhen Ye: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Ah Young Lee: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Chia-An Yen: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Anthony D. Schmitt: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Celso A. Espinoza: Ludwig Institute for Cancer Research, 9500 Gilman Drive
Bing Ren: Ludwig Institute for Cancer Research, 9500 Gilman Drive

Nature, 2013, vol. 503, issue 7475, 290-294

Abstract: A novel approach to analyse high-depth Hi-C data provides a comprehensive chromatin interaction map at approximately 5–10 kb resolution in human fibroblasts; this reveals that TNF-α-responsive enhancers are already in contact with target promoters before signalling and that this chromatin looping is a strong predictor of gene induction.

Date: 2013
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DOI: 10.1038/nature12644

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