Precision is essential for efficient catalysis in an evolved Kemp eliminase

Rebecca Blomberg, Hajo Kries, Daniel M. Pinkas, Peer R. E. Mittl, Markus G. Grütter, Heidi K. Privett, Stephen L. Mayo and Donald Hilvert ()
Additional contact information
Rebecca Blomberg: Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland
Hajo Kries: Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland
Daniel M. Pinkas: Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland
Peer R. E. Mittl: University of Zurich, 8057 Zurich, Switzerland
Markus G. Grütter: University of Zurich, 8057 Zurich, Switzerland
Heidi K. Privett: California Institute of Technology
Stephen L. Mayo: California Institute of Technology
Donald Hilvert: Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland

Nature, 2013, vol. 503, issue 7476, 418-421

Abstract: A computationally designed enzyme that was evolved to accelerate a chemical reaction 6 × 108-fold approaches the exceptional efficiency of highly optimized natural enzymes and provides valuable lessons for the creation of more sophisticated artificial catalysts.

Date: 2013
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DOI: 10.1038/nature12623

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