A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Maria Carolina Florian, Kalpana J. Nattamai, Karin Dörr, Gina Marka, Bettina Überle, Virag Vas, Christina Eckl, Immanuel Andrä, Matthias Schiemann, Robert A. J. Oostendorp, Karin Scharffetter-Kochanek, Hans Armin Kestler, Yi Zheng and Hartmut Geiger ()
Additional contact information
Maria Carolina Florian: University of Ulm, 89091 Ulm, Germany
Kalpana J. Nattamai: Cincinnati Children’s Hospital Medical Center and University of Cincinnati
Karin Dörr: University of Ulm, 89091 Ulm, Germany
Gina Marka: University of Ulm, 89091 Ulm, Germany
Bettina Überle: University of Ulm, 89091 Ulm, Germany
Virag Vas: University of Ulm, 89091 Ulm, Germany
Christina Eckl: Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany
Immanuel Andrä: Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 München, Germany
Matthias Schiemann: Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 München, Germany
Robert A. J. Oostendorp: Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany
Karin Scharffetter-Kochanek: University of Ulm, 89091 Ulm, Germany
Hans Armin Kestler: Institut für Neuroinformatik, University of Ulm, 89091 Ulm, Germany
Yi Zheng: Cincinnati Children’s Hospital Medical Center and University of Cincinnati
Hartmut Geiger: University of Ulm, 89091 Ulm, Germany

Nature, 2013, vol. 503, issue 7476, 392-396

Abstract: This study identifies a shift from canonical to non-canonical Wnt signalling in ageing haematopoietic stem cells (HSCs); elevated expression of Wnt5a in aged HSCs has a causal role in stem-cell ageing, and this is mediated by the small Rho GTPase Cdc42.

Date: 2013
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DOI: 10.1038/nature12631

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