Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

Stephanie K. Dougan, Joseph Ashour, Roos A. Karssemeijer, Maximilian W. Popp, Ana M. Avalos, Marta Barisa, Arwen F. Altenburg, Jessica R. Ingram, Juan Jose Cragnolini, Chunguang Guo, Frederick W. Alt, Rudolf Jaenisch and Hidde L. Ploegh ()
Additional contact information
Stephanie K. Dougan: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Joseph Ashour: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Roos A. Karssemeijer: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Maximilian W. Popp: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Ana M. Avalos: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Marta Barisa: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Arwen F. Altenburg: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Jessica R. Ingram: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Juan Jose Cragnolini: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Chunguang Guo: Boston Children’s Hospital, Karp Family Research Building
Frederick W. Alt: Boston Children’s Hospital, Karp Family Research Building
Rudolf Jaenisch: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Hidde L. Ploegh: Whitehead Institute for Biomedical Research, 9 Cambridge Center

Nature, 2013, vol. 503, issue 7476, 406-409

Abstract: Transnuclear mice are generated from B cells with a receptor specific for the haemagglutinin of influenza A virus; the authors show that influenza virus can infect and deplete haemagglutinin-specific B cells in the lung, which might confer a replicative advantage to the virus and allow it to evade an early neutralizing response.

Date: 2013
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DOI: 10.1038/nature12637

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