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The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

Zachary Gerhart-Hines, Dan Feng, Matthew J. Emmett, Logan J. Everett, Emanuele Loro, Erika R. Briggs, Anne Bugge, Catherine Hou, Christine Ferrara, Patrick Seale, Daniel A. Pryma, Tejvir S. Khurana and Mitchell A. Lazar ()
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Zachary Gerhart-Hines: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Dan Feng: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Matthew J. Emmett: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Logan J. Everett: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Emanuele Loro: Perelman School of Medicine at the University of Pennsylvania
Erika R. Briggs: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Anne Bugge: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Catherine Hou: Perelman School of Medicine at the University of Pennsylvania
Christine Ferrara: Children’s Hospital of Philadelphia
Patrick Seale: The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Daniel A. Pryma: Perelman School of Medicine at the University of Pennsylvania
Tejvir S. Khurana: Perelman School of Medicine at the University of Pennsylvania
Mitchell A. Lazar: Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania

Nature, 2013, vol. 503, issue 7476, 410-413

Abstract: The nuclear receptor Rev-erbα, a powerful repressor of transcription, is shown to link circadian and thermogenic networks by regulating the function of brown adipose tissue.

Date: 2013
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DOI: 10.1038/nature12642

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