HIV-1 evades innate immune recognition through specific cofactor recruitment

Jane Rasaiyaah, Choon Ping Tan, Adam J. Fletcher, Amanda J. Price, Caroline Blondeau, Laura Hilditch, David A. Jacques, David L. Selwood, Leo C. James, Mahdad Noursadeghi () and Greg J. Towers ()
Additional contact information
Jane Rasaiyaah: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK
Choon Ping Tan: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK
Adam J. Fletcher: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK
Amanda J. Price: Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Caroline Blondeau: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK
Laura Hilditch: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK
David A. Jacques: Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
David L. Selwood: Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
Leo C. James: Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Mahdad Noursadeghi: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK
Greg J. Towers: University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK

Nature, 2013, vol. 503, issue 7476, 402-405

Abstract: Human immunodeficiency virus (HIV)-1 is shown here to depend on the recruitment to the HIV-1 capsid of specific cofactors involved in orchestrating nuclear entry and targeting; when these capsid–cofactor interactions are prevented either by virus mutation, cofactor depletion or pharmacological inhibition of cofactor recruitment, viral DNA can be detected by innate immune sensors.

Date: 2013
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DOI: 10.1038/nature12769

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