Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit

Yaser Hashem, Amedee des Georges, Vidya Dhote, Robert Langlois, Hstau Y. Liao, Robert A. Grassucci, Tatyana V. Pestova, Christopher U. T. Hellen () and Joachim Frank ()
Additional contact information
Yaser Hashem: Howard Hughes Medical Institute (HHMI), Columbia University
Amedee des Georges: Howard Hughes Medical Institute (HHMI), Columbia University
Vidya Dhote: SUNY Downstate Medical Center
Robert Langlois: Columbia University
Hstau Y. Liao: Columbia University
Robert A. Grassucci: Columbia University
Tatyana V. Pestova: SUNY Downstate Medical Center
Christopher U. T. Hellen: SUNY Downstate Medical Center
Joachim Frank: Howard Hughes Medical Institute (HHMI), Columbia University

Nature, 2013, vol. 503, issue 7477, 539-543

Abstract: A sub-nanometre reconstruction of a 40S complex containing eIF3 and a hepatitis C virus (HCV)-like internal ribosome entry site (IRES) shows that the IRES displaces eIF3 from the 40S and sequesters it to gain access to the 40S subunit.

Date: 2013
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DOI: 10.1038/nature12658

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