Differential L1 regulation in pluripotent stem cells of humans and apes

Maria C. N. Marchetto, Iñigo Narvaiza, Ahmet M. Denli, Christopher Benner, Thomas A. Lazzarini, Jason L. Nathanson, Apuã C. M. Paquola, Keval N. Desai, Roberto H. Herai, Matthew D. Weitzman, Gene W. Yeo, Alysson R. Muotri and Fred H. Gage ()
Additional contact information
Maria C. N. Marchetto: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Iñigo Narvaiza: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Ahmet M. Denli: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Christopher Benner: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Thomas A. Lazzarini: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Jason L. Nathanson: University of California San Diego, Stem Cell Program, Institute for Genomic Medicine, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA
Apuã C. M. Paquola: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Keval N. Desai: University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Roberto H. Herai: University of California San Diego, School of Medicine, Stem Cell Program, Sanford Consortium, MC 0695, 2880 Torrey Pines Scenic Drive, La Jolla, California 92093, USA
Matthew D. Weitzman: University of Pennsylvania Perelman School of Medicine and Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
Gene W. Yeo: University of California San Diego, Stem Cell Program, Institute for Genomic Medicine, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA
Alysson R. Muotri: University of California San Diego, School of Medicine, Stem Cell Program, Sanford Consortium, MC 0695, 2880 Torrey Pines Scenic Drive, La Jolla, California 92093, USA
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2013, vol. 503, issue 7477, 525-529

Abstract: Induced pluripotent stem-cell characterization reveals phenotypical differences between humans and non-human primates (NHPs): gene expression analysis shows differences in the regulation of long interspersed element-1 (L1) transposons, and in the expression of L1-restricting genes APOBEC3B and PIWIL2, correlating with higher L1 mobility in NHPs; this indicates that L1 mobility differences may have differentially shaped the human and NHP genomes.

Date: 2013
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DOI: 10.1038/nature12686

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