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Structural basis for the modular recognition of single-stranded RNA by PPR proteins

Ping Yin, Quanxiu Li, Chuangye Yan, Ying Liu, Junjie Liu, Feng Yu, Zheng Wang, Jiafu Long, Jianhua He, Hong-Wei Wang, Jiawei Wang, Jian-Kang Zhu, Yigong Shi and Nieng Yan ()
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Ping Yin: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University
Quanxiu Li: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University
Chuangye Yan: Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Ying Liu: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University
Junjie Liu: Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Feng Yu: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China
Zheng Wang: State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
Jiafu Long: State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
Jianhua He: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China
Hong-Wei Wang: Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Jiawei Wang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University
Jian-Kang Zhu: Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Yigong Shi: Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University
Nieng Yan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University

Nature, 2013, vol. 504, issue 7478, 168-171

Abstract: Although the roles of pentatricopeptide repeat (PPR) proteins in RNA metabolism are well characterised, the mechanism by which they recognise specific single-stranded (ss)RNAs remains ill-understood; here X-ray crystal structures of maize PPR10 in the presence and absence of ssRNA provide details of the PPR10–ssRNA interaction.

Date: 2013
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DOI: 10.1038/nature12651

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