Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

Shokrollah Elahi, James M. Ertelt, Jeremy M. Kinder, Tony T. Jiang, Xuzhe Zhang, Lijun Xin, Vandana Chaturvedi, Beverly S. Strong, Joseph E. Qualls, Kris A. Steinbrecher, Theodosia A. Kalfa, Aimen F. Shaaban and Sing Sing Way ()
Additional contact information
Shokrollah Elahi: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
James M. Ertelt: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Jeremy M. Kinder: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Tony T. Jiang: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Xuzhe Zhang: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Lijun Xin: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Vandana Chaturvedi: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Beverly S. Strong: Center for Fetal Cellular and Molecular Therapy, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Joseph E. Qualls: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Kris A. Steinbrecher: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Theodosia A. Kalfa: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Aimen F. Shaaban: Center for Fetal Cellular and Molecular Therapy, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Sing Sing Way: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA

Nature, 2013, vol. 504, issue 7478, 158-162

Abstract: In neonatal mice, susceptibility to infection is due to an enriched subset of arginase-2-expressing CD71+ erythroid cells, which suppresses the systemic activation of immune cells, thereby protecting neonates against aberrant inflammation triggered by colonization with commensal microbes.

Date: 2013
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DOI: 10.1038/nature12675

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