Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Dante Neculai, Michael Schwake, Mani Ravichandran, Friederike Zunke, Richard F. Collins, Judith Peters, Mirela Neculai, Jonathan Plumb, Peter Loppnau, Juan Carlos Pizarro, Alma Seitova, William S. Trimble, Paul Saftig, Sergio Grinstein () and Sirano Dhe-Paganon
Additional contact information
Dante Neculai: Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
Michael Schwake: Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany
Mani Ravichandran: Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Friederike Zunke: Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany
Richard F. Collins: Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
Judith Peters: Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany
Mirela Neculai: Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Jonathan Plumb: Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
Peter Loppnau: Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Juan Carlos Pizarro: Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Alma Seitova: Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
William S. Trimble: Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
Paul Saftig: Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany
Sergio Grinstein: Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
Sirano Dhe-Paganon: Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

Nature, 2013, vol. 504, issue 7478, 172-176

Abstract: These results reveal the first high-resolution structural analysis of LIMP-2 and, by homology modelling, the structure of SR-BI and CD36, members of the CD36 superfamily of scavenger receptor proteins.

Date: 2013
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DOI: 10.1038/nature12684

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