Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

Theresa Alenghat, Lisa C. Osborne, Steven A. Saenz, Dmytro Kobuley, Carly G. K. Ziegler, Shannon E. Mullican, Inchan Choi, Stephanie Grunberg, Rohini Sinha, Meghan Wynosky-Dolfi, Annelise Snyder, Paul R. Giacomin, Karen L. Joyce, Tram B. Hoang, Meenakshi Bewtra, Igor E. Brodsky, Gregory F. Sonnenberg, Frederic D. Bushman, Kyoung-Jae Won, Mitchell A. Lazar and David Artis ()
Additional contact information
Theresa Alenghat: Perelman School of Medicine, University of Pennsylvania
Lisa C. Osborne: Perelman School of Medicine, University of Pennsylvania
Steven A. Saenz: Perelman School of Medicine, University of Pennsylvania
Dmytro Kobuley: Perelman School of Medicine, University of Pennsylvania
Carly G. K. Ziegler: Perelman School of Medicine, University of Pennsylvania
Shannon E. Mullican: Diabetes, and Metabolism, University of Pennsylvania
Inchan Choi: The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
Stephanie Grunberg: Perelman School of Medicine, University of Pennsylvania
Rohini Sinha: Perelman School of Medicine, University of Pennsylvania
Meghan Wynosky-Dolfi: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Annelise Snyder: School of Veterinary Medicine, University of Pennsylvania
Paul R. Giacomin: Perelman School of Medicine, University of Pennsylvania
Karen L. Joyce: Perelman School of Medicine, University of Pennsylvania
Tram B. Hoang: Perelman School of Medicine, University of Pennsylvania
Meenakshi Bewtra: Perelman School of Medicine, University of Pennsylvania
Igor E. Brodsky: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Gregory F. Sonnenberg: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Frederic D. Bushman: Perelman School of Medicine, University of Pennsylvania
Kyoung-Jae Won: The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
Mitchell A. Lazar: Diabetes, and Metabolism, University of Pennsylvania
David Artis: Perelman School of Medicine, University of Pennsylvania

Nature, 2013, vol. 504, issue 7478, 153-157

Abstract: This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene expression and intestinal homeostasis; IEC-specific HDAC3 deficiency gives rise to Paneth cell abnormalities, impaired intestinal barrier function, and increased DSS-induced intestinal inflammation in commensal-bacteria-containing, but not germ-free, mice.

Date: 2013
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DOI: 10.1038/nature12687

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